The role of the pathologist and clinical implications in colorectal liver metastasis
| Journal | Volume 81 - 2018 |
| Issue | Fasc.3 - Case series |
| Author(s) | P. Baldin, M. Van Den Eynde, C. Hubert, A. Jouret-Mourin, M. Komuta |
| Full article |
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| (1) Department of Pathology ; (2) Department of Medical Oncology ; (3) Hepatobiliary Surgery Unit, Department of Abdominal Surgery and Transplantation, Cliniques universitaires Saint-Luc/Université Catholique de Louvain (UCL), Belgium. |
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Colorectal liver metastases (CRLM) affect about 50% of colorectal cancer patients. With the improvement of neoadjuvant chemotherapy and the introduction of targeted therapy, resectability of CRLM and survival rates have improved over time. However, 60-70% of patients still recur. Several pathological and molecular parameters have been described as prognostic factors after CRLM resection. These parameters encompass not only tumoral features, but also non-tumoral ones, such as chemotherapy related liver injury, or factors related to tumour environment, namely Immunoscore. This review summarizes these prognostic indicators to clarify which patho-molecular parameters should be addressed in the pathological report. (Acta Gastroenterol. belg., 2018, 81, 419-426). |
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© Acta Gastro-Enterologica Belgica. PMID 30350532 |
